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Calcium-Sensing Receptor (CaSR)

G protein-coupled receptor on parathyroid chief cells and renal tubule cells that detects extracellular ionized calcium and adjusts PTH secretion and renal calcium handling to maintain plasma calcium.

Also: CaSR

Activating mutations of CaSR cause autosomal dominant hypocalcemia (with inappropriately low PTH); inactivating mutations cause familial hypocalciuric hypercalcemia. Cinacalcet is a calcimimetic that allosterically activates CaSR and is used to lower PTH in CKD-related secondary hyperparathyroidism.

How one textbook covers it

  • Modern Nutrition in Health and Disease, 12th ed. — Ch 7: Calcium

    Activating mutations of CaSR cause autosomal dominant hypocalcemia (with inappropriately low PTH); inactivating mutations cause familial hypocalciuric hypercalcemia. Cinacalcet is a calcimimetic that allosterically activates CaSR and is used to lower PTH in CKD-related secondary hyperparathyroidism.

Related terms

Calcium, PTH