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Glucagon-like Peptide-1 (GLP-1)

Incretin hormone secreted by intestinal L cells in response to nutrients (especially carbohydrates, fats, and SCFAs from microbial fermentation) that stimulates glucose-dependent insulin secretion, delays gastric emptying, and increases satiety via central nervous system action.

Also: GLP-1

GLP-1 receptor agonists (semaglutide, liraglutide, tirzepatide [GLP-1/GIP dual agonist]) have transformed obesity and type 2 diabetes therapeutics, producing 10-20% weight loss in trials. Endogenous GLP-1 secretion is amplified by fermentable fiber via SCFAs activating GPR41/43 on L cells, providing a mechanistic link from fiber to satiety.

How one textbook covers it

  • Modern Nutrition in Health and Disease, 12th ed. — Ch 43: Appetite Regulation

    GLP-1 receptor agonists (semaglutide, liraglutide, tirzepatide [GLP-1/GIP dual agonist]) have transformed obesity and type 2 diabetes therapeutics, producing 10-20% weight loss in trials. Endogenous GLP-1 secretion is amplified by fermentable fiber via SCFAs activating GPR41/43 on L cells, providing a mechanistic link from fiber to satiety.

Related terms

Insulin, Obesity, PYY, SCFA