Leptin resistance
Despite high leptin and adequate receptors, hunger persists and food intake does not diminish.
Reduced biological response to elevated circulating leptin, often observed in obesity. Mechanisms include impaired leptin transport across the blood-brain barrier and intracellular SOCS3/PTP1B signaling inhibition.
How one textbook covers it
Advanced Nutrition and Human Metabolism, 8th ed. (Gropper) — Glossary
Reduced biological response to elevated circulating leptin, often observed in obesity. Mechanisms include impaired leptin transport across the blood-brain barrier and intracellular SOCS3/PTP1B signaling inhibition.
Related terms
Leptin