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Retinoic Acid Receptor (RAR)
Nuclear receptor family (RARα, RARβ, RARγ) that, after binding all-trans retinoic acid, heterodimerizes with RXR and regulates transcription of genes controlling development, immunity, and epithelial differentiation.
Also: RAR, RARα, RARβ, RARγ
RAR-RXR heterodimers bind retinoic acid response elements (RAREs). RARα is the target of all-trans retinoic acid therapy in acute promyelocytic leukemia (PML-RARα fusion). RAR signaling underlies vitamin A's roles in vision (separately, through 11-cis retinal and opsins), embryonic patterning, mucosal immunity (Treg induction, IgA class switching), and squamous-to-mucosal epithelial differentiation.
How one textbook covers it
Modern Nutrition in Health and Disease, 12th ed. — Ch 17: Vitamin A
RAR-RXR heterodimers bind retinoic acid response elements (RAREs). RARα is the target of all-trans retinoic acid therapy in acute promyelocytic leukemia (PML-RARα fusion). RAR signaling underlies vitamin A's roles in vision (separately, through 11-cis retinal and opsins), embryonic patterning, mucosal immunity (Treg induction, IgA class switching), and squamous-to-mucosal epithelial differentiation.
Related terms
RXR, Retinol, Vitamin A