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Retinoid X Receptor (RXR)

Nuclear receptor activated by 9-cis retinoic acid that serves as an obligatory heterodimer partner for RAR, VDR, PPAR, TR, LXR, FXR, and others, making it a central hub of nutrient-sensitive transcription.

Also: RXR, RXRα

RXR's promiscuity means a single retinoid signal can influence vitamin D, thyroid hormone, fatty acid (PPAR), bile acid (FXR), and oxysterol (LXR) gene programs. This positions vitamin A status as a modifier of many nutrient-dependent pathways. Rexinoids (RXR-selective ligands) are explored for cancer and metabolic disease.

How one textbook covers it

  • Modern Nutrition in Health and Disease, 12th ed. — Ch 17: Vitamin A

    RXR's promiscuity means a single retinoid signal can influence vitamin D, thyroid hormone, fatty acid (PPAR), bile acid (FXR), and oxysterol (LXR) gene programs. This positions vitamin A status as a modifier of many nutrient-dependent pathways. Rexinoids (RXR-selective ligands) are explored for cancer and metabolic disease.

Related terms

PPAR, RAR, VDR, Vitamin A