Learn → Glossary → biochemistry

TRPV6

Apical, vitamin D-induced, calcium-selective channel that mediates the entry step of transcellular intestinal calcium absorption.

Also: Transient receptor potential vanilloid 6

TRPV6 is the rate-limiting entry channel for transcellular Ca2+ absorption in the duodenum, working in series with calbindin-D9k and basolateral PMCA1b. Its expression is highly responsive to 1,25(OH)2D. Mouse knockouts of TRPV6 show reduced active calcium absorption but partially compensate via paracellular flux at adequate dietary calcium.

How one textbook covers it

  • Modern Nutrition in Health and Disease, 12th ed. — Ch 7: Calcium

    TRPV6 is the rate-limiting entry channel for transcellular Ca2+ absorption in the duodenum, working in series with calbindin-D9k and basolateral PMCA1b. Its expression is highly responsive to 1,25(OH)2D. Mouse knockouts of TRPV6 show reduced active calcium absorption but partially compensate via paracellular flux at adequate dietary calcium.

Related terms

Calbindin, Calcitriol, PMCA